Lyme disease : from LYMErix to a European vaccine

Table of Contents

Presentation overview

From LYMErix...

LYMErix development: timeline

OspA: Outer Surface Protein A

OspA-based vaccine: initial observations

Protection in mice

Borrelia transmission

Proposed mode of action of OspA-based vaccine

Mechanism of protection

LYMErix®

Auto-immune arthritis?

Lyme vaccine development: timeline

… to a European vaccine

Borrelia variability and distribution

Borrelia burgdorferi sensu lato

OspA variability within Bbss

Proposed composition of European vaccine

Vaccine composition

Lyme Europe vaccine: preclinical data

Trivalent vaccine efficacy in mice (1)

Trivalent vaccine efficacy in mice (2)

Trivalent vaccine efficacy Geographic coverage

Lyme Europe vaccine: clinical data

EULY-002 

EULY-002: Immune response and persistence

European Lyme vaccine development summary

Thanks to...

Email: tulkens@facm.ucl.ac.be

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These slides are for information only. Do not make public use of them without the autorization of their author and of the SBIMC-BVIKM. 

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