PPT Slide

Signaling pathways downstream of TLRs

TLR4

LPS

?

sCD14

LBP

IRAK-1

TRAF6

Cytokine gene induction

TH1 responses

Costimulatory molecule induction

( T cell stimulation )

IFN-inducible gene expression

NF-?B

NF-?B

TIRAP

PKC e ?

TLR2

MyD88

MD-2

PGN

IRAK-2

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