AB treatment in childhood BM

• 20 RCTs evaluated, 2 excluded (1960-2000)

  Few children under 1 month of age
  
  10/20 with acceptable methodology

• 3 major pathogens evaluated: H. influenzae b > N. meningitidis > S. pneumoniae

• Type 2 error: sub-analysis by pathogen

  Most studies < 100 evaluable patients
  

• No study with resistant strains of S. pneumoniae or with L. monocytogenes

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