Treatment of neutropenic patients
Several large scale trials published since 10 years, showing similar efficacy of :
- ceftazidime/piperacillin- tobra (De Pauw Ann. Int. Med., ‘94)
- 696 episodes 61-62% satisfact. response
- Imipenem/ ceftazidime ? amikacin (Rolston Arch. Int Med,’92)
- 750 épisodes 72-71/59% satisfact. response
- Meropenem/ ceftazidime ? amikacin (Cometta AAC, 1996)
- 56-52% satisfact. response
- Place of cefepime alone ? (in units with high rate of ?-lactam hyperproducing Enterobacter, Citrobacter, Serratia,... )