From nalidixic acid to the 1st fluoroquinolone (1 of 4)

nalidixic acid

* Belgian patent 863,429, 1978 to Kyorin

N

C

O

F

O

-

O

HN

N

CH

3

norfloxacin *

1978

2

1

3

combine all 3

features *...

broader Gram(-) activity

less protein binding (50%)

longer half-life (3-4h)

* 6-fluoro-7-pyrimidino-quinoleine

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