From nalidixic acid to the 1st fluoroquinolone (1 of 4)

nalidixic acid

3. introduce a  piperazine *

N

N

N

C

O

C

2

H

5

O

-

O

N

HN

N

N

C

O

C

2

H

5

O

-

O

H

3

C

pipemidic acid *

shows longer half-life...

* pyrido-2-3-pyrimidine

* Ger. Pat. to Roger Bellon, 1974

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