From nalidixic acid to the 1st fluoroquinolone (1 of 4)

nalidixic acid

2. discovery of

flumequine *

flumequine *

shows weak but broad Gram(-) activity

N

N

C

O

C

2

H

5

O

-

O

H

3

C

* Ger pat. to Rikker Labs, 1973

N

C

O

F

O

-

O

CH

3

* benzo-quinolizine

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