Nalidixic acid *

* Belg. pat. 612,258 to Sterling Drugs, 1962

-

• typical chemical features of  fluoroquinolones (a, b, c) BUT a naphthridone (N at position 8: )

• limited usefulness as drug
  • narrow antibacterial spectrum  (Enterobacteriaceae only)
  • short half-life (1.5h)
  • high protein binding (90%)

a

b

c

N

N

C

O

C

2

H

5

O

-

O

H

3

C

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